Elif Ari
Istanbul Bahcesehir University,Turkey
Title: A Prospective Study of Living Kidney Donors: 6 Years Follow-up From A Cardiovascular Disease Risk Perspective
Biography
Biography: Elif Ari
Abstract
Aim
The purpose of the current prospective study was to evaluate the clinical, laboratory and donation-specific outcomes of living kidney donors 6 years after donation.
Methods
We included a total of 93 kidney donors and 54 age- and sex- matched individuals as control group through a prospective consecutive recruitment. We detected kidney function abnormalities, as well as presence of hypertension (HT), diabetes and cardiovascular events during the 6 years follow-up period.
Results
Mean serum creatinine levels were higher (p<0.001) and estimated glomerular filtration rate (eGFR) levels were lower (p<0.001) in living kidney donors 6 years after donation when compared to age- and sex- matched controls. Protein/creatinine ratio of the study population was also higher (p=0.014) after 6 years when compared to controls. There was no difference in outcomes between the groups for end-stage kidney disease (ESKD) and cardiovascular mortality after follow-up period. A higher rate of new-onset HT (6.4% vs 32.9%), diabetes (0.0% vs 4.3%), chronic kidney disease (0.0% vs 2.1%) and cardiovascular disease (0.0% vs 2.1%) was demonstrated among donors 6 years after donation (p<0.001, respectively).
Conclusion
Our data have demonstrated that the reduction in GFR induced by kidney donation might cause an increase in adverse renal and cardiovascular events.