Chia-I Lin
NCKU, Taiwan
Title: The association between gut microbiota, metabolome and kidney function decline
Biography
Chia-I Lin is a graduate student from Department of Food Safety/Hygiene and Risk Management, National Cheng Kung University. She has passion in research and is willing to work hard to overcome difficulties. In the level of her food science degree, Chia-I spent her summers working in food processing industry. Those experiences convinced her to continue to study in food safety and risk management. Her current research is focus on metabolomics and gut microbiota for providing new discoveries in precision medicine which is a treatment option to delay progression of kidney disease.
Abstract
Chronic kidney disease (CKD) is defined by having abnormalities of kidney function or structure present for more than 3 months. CKD is an expensive financial burden for the healthcare system due to the majority of patients with early CKD stage are unrecognized, and that may probably delay diagnosis and progression to End Stage Renal Disease (ESRD). In general, kidney function declines with age in almost everyone. However, few CKD patients’ kidney function sudden drop unexplainedly. The connection between gut and kidney, which is called the gut-kidney axis, had been proposed. The gastrointestinal tract has a regulatory effect on kidney function. The results showed that the interaction between CKD and microbiota affects the host pathophysiological metabolism. Gut dysbiosis in CKD is accompanied by systemic inflammation and comorbid diseases, resulting in dysregulation of metabolic pathways.
Yu Chi
National Cheng Kung University Hospital, Taiwan
Title: Effects of exposure to organophosphate pesticides on renal function and metabolomic signatures of patients with chronic kidney disease
Biography
With a background in the department of Food Science before, I committed myself to solving problems in food safety, the factors that need to be considered and the level of evaluation often involve food chemistry, food microbes, and food processing, it is necessary to understand the hazards that will occur during the food manufacturing process to further control safety. After doing different research including food development and application of plasma in aquaculture. Also, I tried to figure out the relationship between diet and human health. Now studying in the metabolomic study mainly focus on the effects of exposure to OP pesticides on CKD patients in Taiwan. It aims to investigate the impact of exposure to OPs on metabolic pathways and disease progression in CKD patients in three to five stages. I hope that the research can contribute to our society and improve the well-being of these patients.
Abstract
In Taiwan, organophosphates pesticides (OPPs) account for a quarter of the total use of the registered pesticides in Taiwan. Six dialkyl phosphates (DAP) metabolites are excreted in the urine after people expose to OP pesticides. OP may inhibit the activity of acetylcholinesterase in the body, and then exhibits toxic effects on the nervous system, liver, and kidneys. The possible effects of OP residues in crops on sensitive groups have attracted much attention in recent years. Blood circulation, electrolyte balance and excretion in kidneys are partly controlled by cholinergic, therefore, exposure to OP pesticides may impair renal function. High dose exposures in short period may cause acute kidney injury, and long-term exposure to OP pesticides may affect the progression of Chronic Kidney Disease (CKD). Some studies have observed an association between urine biomarkers of pesticide and CKD, however, no metabolomic study focus on the effects of exposure to OP pesticides on CKD patients. Followed by untargeted metabolomic analysis in plasma and urine using an UPLC Q-TOF-MS. Then to identify the differential metabolites related to disease and phenotype to figure out their related biological metabolic pathways.
